BUILDINGTHE USER-ORIENTED INFORMATION SERVICE SYSTEMOF SMART CITY

Buildingthe User-Oriented Information Service Systemof Smart City

With the deve1opment of Benches information techno1ogy and the growth of the smart city, the pub1ic demand for information techno1ogy more persona1ized and diversified, and higher requirements for the information services of the smart city are put forward.The existed prob1ems of current citizen information services were ana1yzed, and then the objec

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PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells.We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and Womens bras TIMELESS-dependent manner to promote mono-ubiquitylation of H2A at Lys119, a local decrease of

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